Gene targeting of retinoid receptors
Copyright policy )Gene targeting of retinoid receptors
Gene targeting in embryonic stem (ES) cells has been employed to investigate the role of the retinoid receptors and binding proteins both in the mouse as well as in embryocarcinoma cells. It is a powerful technique for the modification of the mouse genome. With more recent refinements in gene targeting technology, it is now possible to introduce more subtle mutations in the murine genome, as well as to investigate gene function in a tissue and temporally-restricted manner. It should also be possible to modify genes in diverse diploid cell lines, to generate diverse model systems for analysis of retinoid receptor function. In this article, some of the basic principles for gene targeting are described.
- Montreal Clinical Research Institute Canada
- University of Montreal Canada
Male, Genome, Receptors, Retinoic Acid, Stem Cells, Cell Culture Techniques, DNA, Embryo, Mammalian, Mice, Inbred C57BL, Blotting, Southern, Mice, Electroporation, Mutation, Gene Targeting, Humans, Animals, Female, Embryo Implantation, Cloning, Molecular
Male, Genome, Receptors, Retinoic Acid, Stem Cells, Cell Culture Techniques, DNA, Embryo, Mammalian, Mice, Inbred C57BL, Blotting, Southern, Mice, Electroporation, Mutation, Gene Targeting, Humans, Animals, Female, Embryo Implantation, Cloning, Molecular
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