
doi: 10.1007/bf02783233
pmid: 9522050
Lipid peroxy radicals (ROO.) were detected by electron spin resonance (ESR) at low temperature after formation by addition of H2O2 into a suspension of mice lymphocytes. If lymphocytes were treated with selenomethionine (Se-Met) prior to addition of H2O2, ROO. formation was inhibited in a fashion that was dependent on Se-Met concentration. Formation of ROO. in the spleen of mice was induced by 60Co irradiation. Animals that were supplemented with Na2SeO3 prior to irradiation exhibited a lower ROO. concentration than that of nontreated animals. Based on our experiments, we have concluded that Se has an oxygen-free radical scavenging effect. This should be a protective effect against lipid peroxy radical cellular attack.
Mice, Electron Spin Resonance Spectroscopy, Animals, Hydrogen Peroxide, Lipid Peroxidation, Lymphocytes, Reactive Oxygen Species, Selenomethionine, Spleen
Mice, Electron Spin Resonance Spectroscopy, Animals, Hydrogen Peroxide, Lipid Peroxidation, Lymphocytes, Reactive Oxygen Species, Selenomethionine, Spleen
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