In this article, we limit our discussion to the management of two major types of adverse drug reactions; those of an allergic nature, with or without a proven IgE mechanism, and those that affect mainly the skin. We do not discuss the diagnosis of these commonly occurring clinical problems, as this aspect is presented in the preceding article (see Vervloet et al., this issue) and, especially as concerns the skin, in a recent publication by Roujeau and Stern (1). Cutaneous eruptions are the most frequent manifestations of drug hypersensitivity. Among patients seen in hospitals with a cutaneous drug reaction, one-third tend to have a fixed drug eruption, one-third an exanthematous reaction, and one-fifth an urticarial or angioedematous reaction. The prevalence of adverse reactions to drugs varies from 6-15% in the general population. It varies, of course, with the number of drugs taken and with the route of administration (oral, iv, etc.). Among hospitalized patients, 20-40% have been reported to have had an adverse drug reaction (1-3). Patients with human immunodeficiency virus (HIV) infection or the acquired immunodeficiency syndrome (AIDS) have an even greater risk of having one or another type of drug reaction, a frequency of from 24-50% having been reported (4). Patients with Sj6gren's syndrome are also at risk. The approach to the treatment of an established presumed drug reaction depends obviously on the type and the severity of the reaction. In all cases, the first thing to do is to identify the drug and to discontinue its administration. We proceed from there.