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image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Annals of Biomedical...arrow_drop_down
image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
Annals of Biomedical Engineering
Article . 1995 . Peer-reviewed
License: Springer TDM
Data sources: Crossref
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Efficient and accurate computation of the electric fields of excitable cells

Authors: E J, Vigmond; B L, Bardakjian;

Efficient and accurate computation of the electric fields of excitable cells

Abstract

The numerical computation of the electric fields produced by excitable cells is important in many applications. Traditionally, a potential formulation was used. An integral formulation based on the differentiation of Green's theorem, which solves directly for the electric field, is presented herein. This is desirable because the electric field is proportional to current density, which can be calculated on the cell membrane. Fredholm equations of the second kind are produced, which are more appropriate than are those of the first kind (produced by formulations based on potential). Analytic formulae are presented to calculate the required matrix entries for zeroth order triangular elements that are generally used for field computations in boundary element methods. Results indicated that significantly more accurate answers may be obtained with significantly less computation by formulating the problem directly in terms of electric field as opposed to potential. This approach has the additional advantage that, for equal intracellular and extracellular conductivities, only one matrix must be generated, and no system of simultaneous equations must be solved; this drastically reduces storage and computation requirements. Examples are given to illustrate this technique and to compare the electric field formulation with the potential formulation.

Related Organizations
Keywords

Surface Properties, Cell Membrane, Electric Conductivity, Computer Simulation, Models, Biological, Electric Stimulation, Cell Physiological Phenomena

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
9
Average
Top 10%
Average
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