Introduction of recombinant DNA technology in clinical genetics has provided a more deeper understanding of the molecular basis of inherited disorders in man. Application of these techniques led to detection as well as prevention of genetic defects in risk-prone families. This paper provides a brief outline of the methods involved in prenatal diagnosis of genetic defects. The advantages of using a new set of genetic markers (restriction fragment length polymorphism) over the traditional immunological and biochemical markers are also indicated. The implications of these recent discoveries in the management of genetic defects are also presented.