Signaling of neuronal cell death by the p75NTR neurotrophin receptor
Copyright policy )Signaling of neuronal cell death by the p75NTR neurotrophin receptor
The neurotrophin receptor (p75NTR) is best known for mediating tropic support by participating in the formation of high-affinity nerve growth factor (NGF) receptor complexes with trkA, however, p75NTR more recently has been shown to act as a bona fide death-signaling receptor, which can signal independently of trkA. This article discusses the evidence for an active role of p75NTR in neuronal cell death and the mechanisms controlling this process, including roles for Bcl-2 family members, the c-jun stress kinase JNK, the transcription factor nuclear factor kappa B (NFkappaB), and caspases.
- Walter and Eliza Hall Institute of Medical Research Australia
- Royal Melbourne Hospital Australia
- Melbourne Health Australia
- University of Queensland Australia
- University of Queensland Australia
Neuronal Survival, Knockout, Apoptosis, Receptor, Nerve Growth Factor, Bcl-2 Family, Stress, Physiological, Nerve Growth Factor, Animals, Nerve Growth-factor, Choline-acetyltransferase, Affinity Ngf Receptor, Nf-kappa-b, Neurons, Cell Death, Neurosciences, Terminal Kinase, Caspase, Signaling, Protein-kinase, Dorsal-root Ganglia, X-deficient Mice, Caspases, Neurotrophin, Cytochrome-c, P75ntr, Pc12 Cells, Signal Transduction
Neuronal Survival, Knockout, Apoptosis, Receptor, Nerve Growth Factor, Bcl-2 Family, Stress, Physiological, Nerve Growth Factor, Animals, Nerve Growth-factor, Choline-acetyltransferase, Affinity Ngf Receptor, Nf-kappa-b, Neurons, Cell Death, Neurosciences, Terminal Kinase, Caspase, Signaling, Protein-kinase, Dorsal-root Ganglia, X-deficient Mice, Caspases, Neurotrophin, Cytochrome-c, P75ntr, Pc12 Cells, Signal Transduction
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