A comparison of trimedoxime, obidoxime, pralidoxime and HI-6 in the treatment of oral organophosphorus insecticide poisoning in the rat

descriptionPublicationkeyboard_double_arrow_right Article 01 Dec 1995 English Publisher:Springer Science and Business Media LLCJournal:Archives of Toxicology, volume 70, pages 119-123 (issn: 0340-5761, eissn: 1432-0738,

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Authors: M, Jokanović; M, Maksimović;

doi: 10.1007/bf02733672

pmid: 8773184

A comparison of trimedoxime, obidoxime, pralidoxime and HI-6 in the treatment of oral organophosphorus insecticide poisoning in the rat

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Abstract

This study summarizes the results of examination of acute oral toxicity of 26 organophosphorus insecticides in rats. The effectiveness of trimedoxime, obidoxime, pralidoxime and HI-6, given with atropine and diazepam, was tested in the treatment of poisoning with 2 LD50 of the insecticides. It was shown that the oximes were potent antidotes in poisoning with phosphate insecticides. Obidoxime, pralidoxime and HI-6 had low effectiveness in the treatment of poisoning with phosphonates and phosphorothiolates. However, none of the oximes was an effective antidote in poisoning with dimethoate and pyridafenthion. Trimedoxime was the most effective oxime in the treatment of insecticide poisoning, being successful especially at the lowest tested doses.

Related Organizations

University of Padua
Italy

Keywords

Atropine, Male, Insecticides, Diazepam, Obidoxime Chloride, Pralidoxime Compounds, Dose-Response Relationship, Drug, Antidotes, Administration, Oral, Rats, Organophosphorus Compounds, Oximes, Animals, Rats, Wistar, Trimedoxime

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