Malignant fibrous histiocytoma is a type of soft tissue sarcoma. Although is usually described as a primary neoplasm it has also been related to previous radiation therapy. We report the case of a 49-year-old woman with a history of chemo-radiotherapy five years before due to a cervix cancer. Five years after, a malignant fibrous histiocytoma was discovered in tattoo radiation fields. A wide resection of the tumor was performed and the abdominal wall defect was covered. Diagnosis of this type of tumors remain controversial, they are very aggressive and surgery is still the treatment of choice.