A review of dehydroepiandrosterone (DHEA)

descriptionPublicationkeyboard_double_arrow_right Article 01 Sep 1995 English Publisher:Springer Science and Business Media LLCJournal:Integrative Physiological and Behavioral Science, volume 30, pages 308-313 (issn: 1053-881X, eissn: 1936-3567,

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Authors: C N, Shealy;

doi: 10.1007/bf02691603

pmid: 8788227

A review of dehydroepiandrosterone (DHEA)

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Abstract

Dehydroepiandrosterone (DHEA) is quantitatively the most abundant hormone in humans and mammals, with a wide variety of physiological effects, including major regulatory effects upon the immune system. Two of the most striking aspects of DHEA are a steady decline in DHEA with age and a significant deficiency in DHEA in patients with several major diseases, including cancer, atherosclerosis, and Alzheimer's disease. The hormone is secreted in a non-sulfated (DHEA) and sulfated form (DHEA-S). The two are apparently interchangeable, and it appears likely that its physiological effects are achieved by derivative molecules that have yet to be identified.

Keywords

Animals, Humans, Dehydroepiandrosterone

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