Corrective effect of clotrimazole and β-ionol during exposure to thiophenol

descriptionPublicationkeyboard_double_arrow_right Article 01 Nov 2000 English Publisher:Springer Science and Business Media LLCJournal:Bulletin of Experimental Biology and Medicine, volume 130, pages 1,090-1,092 (issn: 0007-4888, eissn: 1573-8221,

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Authors: V A, Dadali; N E, Golovanova; R N, Pavlova; N E, Dzhangulova; V E, Vinogradova;

doi: 10.1007/bf02688187

pmid: 11182824

Corrective effect of clotrimazole and β-ionol during exposure to thiophenol

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Abstract

Toxic effect of thiophenol on rats can be prevented by injection of antioxidant beta-ionol and clotrimazole, an inductor of phase I and II detoxication enzymes. Both agents increase o-demethylase activity of cytochrome P-450, but do not prevent inhibition of its water-soluble form, and activate cytosol and microsomal glutathione-dependent enzymes. Both agents protected erythrocytes from peroxide damage by thiophenol and simultaneously enhanced its prooxidant effect in the liver.

Keywords

Male, Free Radicals, Terpenes, Erythrocyte Membrane, Butylated Hydroxytoluene, Catalase, Antioxidants, Rats, Hemoglobins, Glutathione Reductase, Cytochrome P-450 Enzyme System, Phenols, Enzyme Induction, Animals, Sulfhydryl Compounds, Clotrimazole, Norisoprenoids, Glutathione Transferase

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