Antioxidant properties of thiamine

descriptionPublicationkeyboard_double_arrow_right Article 01 Sep 2000 English Publisher:Springer Science and Business Media LLCJournal:Bulletin of Experimental Biology and Medicine, volume 130, pages 874-876 (issn: 0007-4888, eissn: 1573-8221,

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Authors: P I, Lukienko; N G, Mel'nichenko; I V, Zverinskii; S V, Zabrodskaya;

doi: 10.1007/bf02682257

pmid: 11177269

Antioxidant properties of thiamine

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Abstract

Thiamine (10(-4)-10(-6)M) inhibits lipid peroxidation in rat liver microsomes and free radical oxidation of oleic acid in vitro. Thiamine interacts with free radicals and hydroperoxides and is oxidized to thiochrome and thiamine disulfide. The antioxidant effect of thiamine is probably related to successive transfer of 2H(+)from the NH(2)group of the pyrimidine ring and H(+)from the thiazole ring (after its opening) to reactive substrates.

Keywords

Male, Mice, Microsomes, Liver, Animals, Thiamine, Antioxidants

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