Effect of semax on homeostasis of gastric mucosa in albino rats

descriptionPublicationkeyboard_double_arrow_right Article 01 Sep 2000 English Publisher:Springer Science and Business Media LLCJournal:Bulletin of Experimental Biology and Medicine, volume 130, pages 871-873 (issn: 0007-4888, eissn: 1573-8221,

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Authors: S E, Zhuikova; E A, Smirnova; Z V, Bakaeva; G E, Samonina; I P, Ashmarin;

doi: 10.1007/bf02682256

pmid: 11177268

Effect of semax on homeostasis of gastric mucosa in albino rats

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Abstract

The ACTH(4-7)analogue Semax administered intraperitoneally in a dose of 50 microg/kg 1 h before exposure to ulcerogenic factors (ethanol, water immersion immobilization stress) protected gastric mucosa from damage. Postoperative treatment with Semax for 5 days after application of glacial acetic acid on the mucosa prevented acetic acid-induced ulcers and promoted their healing. The antiulcer effects of Semax in the studied dose were comparable with those of tripeptide Pro-Gly-Pro in a dose of 1 mg/kg.

Related Organizations

Lomonosov Moscow State University
Russian Federation

Keywords

Neuroprotective Agents, Adrenocorticotropic Hormone, Gastric Mucosa, Animals, Homeostasis, Stomach Ulcer, Peptide Fragments, Rats

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