Thromboangiitis obliterans (TAO) is very frequent in eastern Anatolia. In a ten-year period 204 Buerger’s disease patients were diagnosed in Ataturk University Research Hospital. The patients were 18 to 45 years old (mean 28.4 years). Of these patients 185 were chronic smokers, 124 were from a lower socioeconomic level, and 137 were living in a cold climate. Cryoglobulin was positive in 48 patients.