An experimental program was conducted to characterize creep strength differential (CSD) effects in Zircaloy-2 by the determination of differences in the magnitude of creep deformation in specimens under uniaxial tension and compression. The texture dependence of creep in these specimens was also characterized. Uniaxial thermal creep tests were conducted in tension and compression at 325 to 400 °C and 69 to 172 MPa on specimens taken from the three principal directions of textured Zircaloy-2 plate fabricated in both the recrystallized and the cold-worked, stress relieved condition. Stress relaxation tests were conducted at 400 °C on similar specimens to substantiate results of the thermal creep tests. Creep strength-differential effects were found in all three principal directions of both types of plate, and it appeared that the CSD was larger in the longitudinal than the normal direction. Creep strains in tension were as much as three times larger than those in compression. In addition, the relative magnitude of creep strains indicated that the tensile creep strength at 400 °C was proportional to the resolved fraction of basal poles in the test direction. Cold work attenuated this anisotropy, and “transitions’in some creep tests on recrystallized material reversed this anisotropy. Finally, the thermal creep data were used to construct creep loci which graphically illustrate these characteristics.