Variation in S phase in synchronous human cell lines
Copyright policy )Variation in S phase in synchronous human cell lines
Growth parameters of diploid and trisomic human fibroblasts were determined. The rate of growth of both classes of cells was examined in asynchronous cultures, and diploid and trisomic cells had similar growth rates. Synchronous cultures were developed using simple mitotic selection. The patterns and length of the DNA synthetic period (S phase) were found to be altered in trisomy 21 cells when compared to diploid human or to heteroploid HeLa cells. Early S-phase synthesis was absent or reduced and the overall length of the S phase was extended. However, the trisomic cells have apparently normal rates of DNA chain elongation and normal replicon sizes.
- State University of New York United States
- State University of New York at Potsdam United States
- University of California, San Francisco United States
- University of Washington United States
- University of Mary United States
DNA Replication, Time Factors, Cell Cycle, DNA, DNA, Neoplasm, Fibroblasts, Diploidy, Cell Line, Humans, Down Syndrome, Interphase, Cell Division, HeLa Cells
DNA Replication, Time Factors, Cell Cycle, DNA, DNA, Neoplasm, Fibroblasts, Diploidy, Cell Line, Humans, Down Syndrome, Interphase, Cell Division, HeLa Cells
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