Geochemistry of Pliocene to recent volcanic rocks from Los Humeros caldera (19°30′ N – 19°50′ N and 97°15° W – 97°35′ W) in East-Central mexico is described. The volcanic rocks from this area seem to represent both alkali and high-alumina basalt series, or both calcalkaline and high-K calc-alkaline sequences. The available bulk-chemical analyses (23 this study and 18 from unpublished literature) show that the entire sequence of rocks from basalts to rhyolites are present in this area. Different degrees of partial melting of the source region followed by extensive shallow-level crystal differentiation seem to have taken place before most volcanic eruptions. These processes are perhaps the most important mechanisms for magma genesis in Los Humeros caldera. Geophysical studies in this area are not sufficient and more detailed geophysical surveys and a better geological interpretation are needed in order to delimit the underlying magma chamber.