ATP-citrate lyase activity in fungal extracts

Name: ATP-citrate lyase activity in fungal extracts
Creator: M M, Attwood
Keywords: 0301 basic medicine, 0303 health sciences, Cell-Free System, Oxaloacetates, Fungi, Oxo-Acid-Lyases, Hydrogen-Ion Concentration, Culture Media, 03 medical and health sciences, Adenosine Triphosphate

M M, Attwood

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Antonie van Leeuwenh...arrow_drop_down

Antonie van Leeuwenhoek

Article . 1973 . Peer-reviewed

License: Springer TDM

Data sources: Crossref

Antonie van Leeuwenhoek

Article . 1974

Data sources: Europe PubMed Central

https://dx.doi.org/10.1007/bf0...

Article

Data sources: Microsoft Academic Graph

ATP-citrate lyase activity in fungal extracts

descriptionPublicationkeyboard_double_arrow_right Article 01 Dec 1973 English Publisher:Springer Science and Business Media LLCJournal:Antonie van Leeuwenhoek, volume 39, pages 539-544 (issn: 0003-6072, eissn: 1572-9699,

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Authors: M M, Attwood;

doi: 10.1007/bf02578898

pmid: 4543060

ATP-citrate lyase activity in fungal extracts

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Abstract

ATP-citrate lyase activity has been demonstrated in crude extracts from several species ofMortierella. This filamentous fungus characteristically stores lipid in the mycelium. The enzyme catalyses an ATP-dependent cleavage of citrate in the presence of CoA to oxaloacetic acid and acetylCoA. A partially purified preparation has been obtained and shown to have properties similar to preparations isolated from other sources. It is highly specific for citrate and ATP and has an optimum pH value for activity of 8.4. When the fungus is grown in the presence of increasing amounts of glucose the specific activity of the enzyme also increases.

Related Organizations

University of Sheffield
United Kingdom

Keywords

Cell-Free System, Oxaloacetates, Fungi, Oxo-Acid-Lyases, Hydrogen-Ion Concentration, Culture Media, Adenosine Triphosphate, Glucose, Species Specificity, Ammonium Sulfate, Spectrophotometry, Chemical Precipitation, Coenzyme A, Magnesium, Citrates, Ultracentrifugation

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