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image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Lipidsarrow_drop_down
image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
Lipids
Article . 1993 . Peer-reviewed
License: Wiley Online Library User Agreement
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Lipids
Article . 1993
Data sources: Europe PubMed Central
Lipids
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Protein kinase C‐dependent stimulation of phospholipase D in phospholipase C‐treated fibroblasts

descriptionPublicationkeyboard_double_arrow_right Article 01 Jun 1993Publisher:WileyJournal:Lipids, volume 28, pages 479-481 (issn: 0024-4201, eissn: 1558-9307, Copyright policy )
Authors: Zoltan Kiss; Nandor Garamszegi;

doi: 10.1007/bf02536077

pmid: 8355574

Protein kinase C‐dependent stimulation of phospholipase D in phospholipase C‐treated fibroblasts

Abstract

AbstractTreatment of [14C]choline‐ or [14C]ethanolamine‐labeled NIH 3T3 fibroblasts withBacillus cereus phosphatidylcholine‐specific phospholipase C (PLC) enhanced phospholipase D (PLD)‐mediated hydrolysis of the respective14C‐labeled phospholipids. PLD activity was stimulated by 1.5 U/mL of POLC and by 100 nM of the protein kinase C (PKC) activator phorbol 12‐myristate 13‐acetate (PMA) to similar extents. Treatment of14C]palmitic acid‐labeled fibroblasts with PLC in the presence of ethanol also enhanced PLD‐mediated formation of phosphatidylethanol; the effects of PLC and PMA were nonadditive. PLC had no effect on PLD activity in fibroblasts in which PKC was down‐regulated by prolonged (24 h) treatment with 300 nM PMA. These data indicate that treatment of fibroblasts with exogenous PLC results in PKC‐dependent activation of PLD.

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Keywords

Dose-Response Relationship, Drug, Hydrolysis, Phosphatidylethanolamines, Phosphorylcholine, 3T3 Cells, Fibroblasts, Choline, Mice, Type C Phospholipases, Phosphatidylcholines, Phospholipase D, Animals, Tetradecanoylphorbol Acetate, Phospholipids, Protein Kinase C

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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
2
Average
Average
Average
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