Hydroxylation of secondary bile acids in the perfused prairie dog liver
Copyright policy )Hydroxylation of secondary bile acids in the perfused prairie dog liver
AbstractTaurolithocholic acid and deoxycholic acid were perfused into isolated prairie dog livers. Taurolithocholic acid was 7α‐hydroxylated to form taurochenodeoxycholic acid, whereas deoxycholic acid was conjugated and 7α‐hydroxylated to form taurocholic acid. The low concentrations of secondary bile acids observed in prairie dog bile are due, at least in part, to active bile acid 7α‐hydroxylase(s) in the liver of these animals.
- United States Department of Veterans Affairs United States
- Beth Israel Deaconess Medical Center United States
- Icahn School of Medicine at Mount Sinai United States
Male, Rodentia, In Vitro Techniques, Hydroxylation, Bile Acids and Salts, Perfusion, Liver, Animals, Female, Chromatography, Thin Layer, Chromatography, High Pressure Liquid, Deoxycholic Acid, Taurolithocholic Acid
Male, Rodentia, In Vitro Techniques, Hydroxylation, Bile Acids and Salts, Perfusion, Liver, Animals, Female, Chromatography, Thin Layer, Chromatography, High Pressure Liquid, Deoxycholic Acid, Taurolithocholic Acid
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