Red blood cell tocopherol and liver tocopherol in hyperlipemic rats as compared with plasma tocopherol

descriptionPublicationkeyboard_double_arrow_right Article 01 Jul 1985 English Publisher:WileyJournal:Lipids, volume 20, pages 488-491 (issn: 0024-4201, eissn: 1558-9307,

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Authors: M, Mino; O, Kasugai; T, Shimizu;

doi: 10.1007/bf02534241

pmid: 4033367

Red blood cell tocopherol and liver tocopherol in hyperlipemic rats as compared with plasma tocopherol

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Abstract

AbstractIn rats with hyperlipemia induced by Triton WR‐1339, changes in tocopherol concentrations in plasma and RBC were compared with those in the liver and its subcellular fractions, microsomes and mitochondria.After daily injection with Triton, plssma total lipids at 3 days and 7 days, respectively, showed elevation 6.5 times and 15 times as high as those in the control rats, and triglycerides showed the most predominant elevation.With the hyperlipemia, the concentrations of tocopherol in RBC and the subcellular fractions decreased, as plasma lipids and plasma tocopherol increased, while no change occurred in tocopherol concentrations in liver homogenates. The changes in the ratio of tocopherol to total lipids in plasma coincided with changes in tocopherol concentrations in the RBC and subcellular fractions.

Keywords

Male, Erythrocytes, Detergents, Hyperlipidemias, Rats, Inbred Strains, Polyethylene Glycols, Rats, Liver, Animals, Vitamin E

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