Inhibition of diacylglycerol: CDPcholine cholinephosphotransferase activity by dimethylaminoethylp‐clorophenoxyacetate

descriptionPublicationkeyboard_double_arrow_right Article 01 Feb 1978 English Publisher:WileyJournal:Lipids, volume 13, pages 161-164 (issn: 0024-4201, eissn: 1558-9307,

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Authors: S, Parthasarathy; R K, Cady; D S, Kraushaar; N E, Sladek; W J, Baumann;

doi: 10.1007/bf02533260

pmid: 204847

Inhibition of diacylglycerol: CDPcholine cholinephosphotransferase activity by dimethylaminoethylp‐clorophenoxyacetate

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Abstract

AbstractCholinephosphotransferase [EC 2.7.8.2] activity of rat liver microsomes, with 1,2‐di‐0‐[3H]acyl glycerol or 1‐0‐hexadecanoyl [U‐14C]ethanediol as substrate, was inhibited byN,N‐dimethylaminoethylp‐chlorophenoxyacetate (centrophenoxine). Inhibition progressed in a linear fashion with increasing drug levels and was complete at 30 mM concentration. It appears that the microsomal enzyme was largely affected by the drug itself because the hydrolysis products of centrophenoxine, viz.,N,N‐dimethylaminoethanol andp‐chlorophenoxyacetic acid, were less inhibitory.

Related Organizations

University of Minnesota Morris
United States
University of Minnesota
United States

Keywords

Meclofenoxate, Dose-Response Relationship, Drug, Diacylglycerol Cholinephosphotransferase, Phosphotransferases, Microsomes, Liver, Animals, Glycolates, Rats

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