Mevalonate biosynthesis in rat liver

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1970 English Publisher:WileyJournal:Lipids, volume 5, pages 104-108 (issn: 0024-4201, eissn: 1558-9307,

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Authors: G M, Fimognari; V W, Rodwell;

doi: 10.1007/bf02531103

pmid: 4392126

Mevalonate biosynthesis in rat liver

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Abstract

AbstractMevalonate synthesis in rat liver can occur not only from HMG‐CoA utilizing particle‐bound HMG‐CoA reductase, but from malonyl‐CoA utilizing soluble enzymes. From a strictly quantitative standpoint, synthesis from malonyl‐CoA appears to be of minor importance. The possible regulatory significance of two parallel routes to mevalonate is discussed.

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Keywords

Carbon Isotopes, Air, Mevalonic Acid, Acetates, Malonates, Rats, Glutarates, Alcohol Oxidoreductases, Bicarbonates, Liver, Animals, Coenzyme A, Hexosephosphates, Ultracentrifugation, NADP

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