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image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Medical & Biological...arrow_drop_down
image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
Medical & Biological Engineering & Computing
Article . 1999 . Peer-reviewed
License: Springer TDM
Data sources: Crossref
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Mechanical and electromotile characteristics of auditory outer hair cells

Authors: A A, Spector; W E, Brownell; A S, Popel;

Mechanical and electromotile characteristics of auditory outer hair cells

Abstract

The passive and active properties of the cochlear outer hair cell are studied. The outer hair cell is currently considered the major candidate for the active component of mammalian hearing. Understanding of its properties may explain the amplification and sharp frequency selectivity of the ear. To analyse the cell behaviour, a model of a nonlinear anisotropic electro-elastic shell is used. Using the data from three independent experiments, where the mechanical strains of the cell are measured, estimates of the cell wall in-plane Young's moduli and Poisson's ratios are given, as well as estimates of three modes of bending stiffness. Based on these estimates and data from the microchamber experiment, where the cell is under the action of transmembrane potential changes, the characteristics of the outer hair cell active behaviour are found. These characteristics include the coefficients of the active force production per unit of the transmembrane potential change and limiting parameters of the electromotile response for extreme hyperpolarisation and depolarisation of the cell. The obtained estimates provide important information for the modelling of organ-level cochlear mechanics.

Related Organizations
Keywords

Electrophysiology, Hair Cells, Auditory, Outer, Hearing, Humans, Models, Biological, Biomechanical Phenomena

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
11
Average
Top 10%
Average
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