Beyond ribosomal DNA: on towards the telomere

descriptionPublicationkeyboard_double_arrow_right Article 01 Jun 1997 English Publisher:Springer Science and Business Media LLCJournal:Chromosoma, volume 105, pages 431-437 (issn: 0009-5915, eissn: 1432-0886,

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Authors: I L, Gonzalez; J E, Sylvester;

doi: 10.1007/bf02510479

pmid: 9211970

Beyond ribosomal DNA: on towards the telomere

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Abstract

We have sequenced and analyzed 8.3 kb of sequence adjacent and distal to the human ribosomal DNA (rDNA); this distal sequence connects to the rDNA cluster just 4 kb upstream of the first promoter and is shared among the acrocentric chromosomes and, at least in part, it is also present in other primates. The sequence differs in character from that of the rDNA intergenic spacer (IGS) in that it does not contain long stretches of either polypyrimidine or polypurine. However, just like the IGS, it contains numerous repetitive elements, including retroposed fragments of 28S rRNA and large pieces of the IGS. In addition, we show that the rDNA clusters are not interrupted by other sequences and do not recombine with this distal segment.

Related Organizations

Allegheny University of the Health Sciences
United States

Keywords

Primates, Base Sequence, Databases, Factual, Chromosome Mapping, Sequence Analysis, DNA, Telomere, DNA, Ribosomal, Electrophoresis, Gel, Pulsed-Field, Animals, Chromosomes, Human, Humans, Cloning, Molecular, Sequence Alignment, Conserved Sequence, Repetitive Sequences, Nucleic Acid

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