Stereotactic biopsy is presently performed routinely in the histological diagnosis of brain tumors before the start of chemotherapy. We present a case of accidental total subarachnoid block (TSB) [1] in which neurosurgical stereotactic operations were repeatedly conducted under local anesthesia. There are reports of accidental TSB following durapuncture in spinal epidural anesthesia or intentional TSB for the treatment of intractable pain [2]. Our report describes a case of unexpected, temporary coma and apnea that are presumed to have resulted from accidental direct penetration of a local anesthetic agent into the cerebral ventricular system during local scalp anesthesia.