When an experimenter determines the “internal concentration” of a substance in a cell (or cell suspension) it is in general the average concentration (quantity of substance divided by cell volume or volume of cell water) which is measured. When this concentration is less than that in the ambient medium but there is either no flow into the cell or flow from the cell into the medium, then (under the usually tacit assumption of spatial uniformity in the cell) the possibility of active transport is considered. The possibility that lack of spatial uniformity could lead to apparent active transport was early proposed by A. Bierman and later examined quantitatively by N. Rashevsky for a special case. In this paper spherical cells are treated but under quite general conditions regarding the metabolic aspects of the problem. It is shown that apparent active transport can result for a metabolite which is a reactant in one set of reactions and a product in another provided the sites of these sets of reactions are spatially separated in the cell.