Serotonin-reactive neurons in the neocortex

descriptionPublicationkeyboard_double_arrow_right Article 01 Sep 1997 English Publisher:Springer Science and Business Media LLCJournal:Neuroscience and Behavioral Physiology, volume 27, pages 489-491 (issn: 0097-0549, eissn: 1573-899X,

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Authors: V A, Otellin; D E, Korzhevskiĭ;

doi: 10.1007/bf02463889

pmid: 9353765 , 8983500

Serotonin-reactive neurons in the neocortex

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Abstract

In the course of study performed on Wistar line rats using light and electron microscopy it was found that brain serotoninergic system damage by the selective neurotoxin of 5,7 dihydroxytryptamine leads to degenerative changes in certain pyramidal neurons of the motor cortex superficial layers. Deep layers pyramid neurons acquire the signs of functional activity increase with the appearance of intranuclear inclusions. The results obtained are discussed with taking to consideration the impact of serotoninergic system damage on the neuropsychic diseases pathogenesis.

Related Organizations

Academy of Medical Sciences
United Kingdom
Russian Academy

Keywords

Cerebral Cortex, Male, Neurons, Serotonin, Time Factors, Adrenergic Uptake Inhibitors, 5,7-Dihydroxytryptamine, Desipramine, Neocortex, Serotonin Receptor Agonists, Rats, Norepinephrine, Microscopy, Electron, Serotonin Agents, Animals, Rats, Wistar

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