Effect of antagonists and agonists of 5-HT1 and 5-HT2 serotonin receptors on the predator aggressiveness of wild norway rats

descriptionPublicationkeyboard_double_arrow_right Article 01 Jun 1996 English Publisher:Springer Science and Business Media LLCJournal:Bulletin of Experimental Biology and Medicine, volume 121, pages 621-623 (issn: 0007-4888, eissn: 1573-8221,

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Authors: N. K. Popova; E. M. Nikulina; S. N. Shigantsov; I. F. Plyusnina; T. G. Amstislavskaya;

doi: 10.1007/bf02447135

Effect of antagonists and agonists of 5-HT1 and 5-HT2 serotonin receptors on the predator aggressiveness of wild norway rats

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Abstract

The effect of agonists of serotonin receptors on predator aggressiveness (the “mouse killing” test) is studied on Norway rats. Ipsapirone and eltoprazine are found to have no effect on predator aggressiveness. 1-[3-(Trifluoromethyl)phenyl]piperazine×HCl (TFMPP) considerably reduces aggressiveness. The serotonin precursor 5-hydroxyptryptophan also lowers it, while the antagonist of 5-HT2A receptors ketanserin abolishes the inhibitory effect of 5-hydroxytryptophan. Presumably, the inhibitory effects of serotonin on predator aggressiveness are realized via the 5-HT2A and 5-HT2C brain serotonin receptors.

Related Organizations

Institute of Cytology and Genetics
Russian Federation
Russian Academy of Sciences
Russian Federation

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