Role of α2-adrenoceptors in brain resistance to total ischemiaadrenoceptors in brain resistance to total ischemia

descriptionPublicationkeyboard_double_arrow_right Article 01 Oct 1997 English Publisher:Springer Science and Business Media LLCJournal:Bulletin of Experimental Biology and Medicine, volume 124, pages 984-987 (issn: 0007-4888, eissn: 1573-8221,

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Authors: V. I. Kulinskii; T. N. Medvedeva;

doi: 10.1007/bf02446840

Role of α2-adrenoceptors in brain resistance to total ischemiaadrenoceptors in brain resistance to total ischemia

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Abstract

Neuroprotective effect of epinephrine is revealed against the background of prazosin, β-antagonists and their combinations protect against cerebral ischemia. α2-Antagonists (but not α1) block the neuroprotective effect of these combinations, methyldopa, guanabenz, clonidine, and oxymetazoline and decrease brain resistance to ischemia. α2-Adrenoreceptors participate in the endogenic mechanism of brain resistance to ischemia and in the neuroprotective effect.

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Irkutsk State Medical University
Russian Federation

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