A high pressure pulse, which was produced by a shock tube, was hit repeatedly on a pellet of mouse EL-4 T-lymphoma cells packed in a small test tube which was filled up with culture medium. The pressure pulse measured at the conical bottom of the tube had about 30 μs width and up to 8.4 MPa height depending on the driver gas pressure of the shock tube. The lymphoma cells began to be destroyed by hitting with 100 pulses having a peak pressure around 3 MPa. The fraction of dead cells in the tube exposed to the shock wave of 100 pulses rose exponentially as the peak pressure was increased from 3 MPa to 8 MPa. The fraction of dead cells at 6.0 MPa of the peak pressure was around 10%. However, proliferative function of the cells survived after exposure to 6.0 MPa-peak-pressure pulses seemed intact because the cells which survived the exposure proliferated as well as the nonexposed control cells.