AbstractA new technique of application of cyanoacrylate tissue adhesive has been evaluated in 180 patients with wounds of the liver (77 patients), spleen (12 patients), pancreas (9 patients), and lung (82 patients). The technique involves injection of the tissue adhesive with a specially adapted jet injector, so that it penetrates 3–5 mm deep into the parenchyma to form an adhesive plug. The cyanoacrylate adhesive was tolerated without complications, and was highly successful in controlling bleeding, leakage of bile and pancreatic juice, and leakage of air. The adhesive plugging technique warrants widespread application in the surgery of parenchymatous organs.