In Vitro techniques for studying drug metabolism
Copyright policy )In Vitro techniques for studying drug metabolism
A considerable amount of information has been obtained about human enzymes involved in drug metabolism. Cytochrome P450 is presented as a paradigm in order to illustrate the experimental techniques now available. In vitro assays can be done with tissue slices, microsomes, or even short-term cell cultures. In addition, recombinant enzymes can be produced in a variety of different vector systems. Information about catalytic selectivity regarding new drugs can be obtained, as well as important information about potential drug-drug interactions and bioavailability. Such studies play a role in the drug development process as well as metabolism and safety assessment.
- Vanderbilt University United States
Polymorphism, Genetic, Gene Expression, In Vitro Techniques, Antibodies, Enzymes, Cytochrome P-450 Enzyme System, Pharmaceutical Preparations, Drug Design, Enzyme Induction, Microsomes, Liver, Animals, Cytochrome P-450 Enzyme Inhibitors, Humans, Enzyme Inhibitors, Cells, Cultured
Polymorphism, Genetic, Gene Expression, In Vitro Techniques, Antibodies, Enzymes, Cytochrome P-450 Enzyme System, Pharmaceutical Preparations, Drug Design, Enzyme Induction, Microsomes, Liver, Animals, Cytochrome P-450 Enzyme Inhibitors, Humans, Enzyme Inhibitors, Cells, Cultured
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).86 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!