Pulsed nuclear magnetic resonance studies in sickled erythrocytes

descriptionPublicationkeyboard_double_arrow_right Article 01 Mar 1975 English Publisher:Springer Science and Business Media LLCJournal:Journal of Biological Physics, volume 3, pages 42-52 (issn: 0092-0606, eissn: 1573-0689,

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Authors: Anthony A. Silvidi; Dave J. Farrell;

doi: 10.1007/bf02308901

Pulsed nuclear magnetic resonance studies in sickled erythrocytes

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Abstract

Pulsed proton magnetic resonance studies were made to determine T1 (spin-lattice) and T2 (spin-spin) relaxation times for normal and sickled blood cells in the oxygenated and deoxygenated states as a function of temperature between 0°C and 37°C. It was found that the sickling phenomenon affects T2 values but not T1 values in these cells. These results are ascribed to a proton-exchange mechanism. The functional relationship found between T2 and temperature in the sickled cells is similar to that between the formation of hydrophobic bonds and temperature proposed by Nalbandian and Scheraga.

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