Out outbreak of goat pox occurred among 60 adult and young goats in the Sudan. Among the findings of special interest was the extensive and wide distribution of pox lesions on the bodies of the animals. The severe involvement of the mucous membranes of the muzzle, eyes and nostrils gave rise to acute respiratory distress and systemic reaction. The suppression of secondary bacterial infection with local and systemic terramycin in addition to supportive therapy of affected animals alleviated the condition and none of the animals died. Typical pox lesions were produced experimentally on goats and sheep using infected material from goats. Human infections were not encountered.