Retention of retinoids on an aromatic stationary phase in reversed-phase liquid chromatography

descriptionPublicationkeyboard_double_arrow_right Article 01 Nov 1993 English Publisher:Springer Science and Business Media LLCJournal:Chromatographia, volume 37, pages 501-504 (issn: 0009-5893, eissn: 1612-1112,

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Authors: M. Salo; S. Herrala;

doi: 10.1007/bf02275787

Retention of retinoids on an aromatic stationary phase in reversed-phase liquid chromatography

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Abstract

The retention behaviour of retinoids, which are π-electron containing solutes, on a phenyl stationary phase was studied using mobile phases consisting of aqueous methanol (MeOH; 76–84 % v/v) and acetonitrile (ACN; 60–82% v/v) at five temperatures (40–60°C). Retention was increasingly affected in both mobile phases by temperature and molecular structure with increasing water content. The effects of mobile-phase are stronger in MeOH and highly aqueous ACN, retention is enhanced. The π-π interactions have a significant effect on the selectivity of chromatographic separations when the sample compounds differ in their electron donor/acceptor capacities.

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University of Helsinki
Finland

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