Technical manual for manufacturing autologous fibrin tissue adhesive

descriptionPublicationkeyboard_double_arrow_right Article 01 Oct 1999 English Publisher:Ovid Technologies (Wolters Kluwer Health)Journal:Diseases of the Colon & Rectum, volume 42, pages 1,334-1,338 (issn: 0012-3706,

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Authors: J J, Park; J R, Cintron; K H, Siedentop; C P, Orsay; R K, Pearl; R L, Nelson; H, Abcarian;

doi: 10.1007/bf02234225

pmid: 10528774

Technical manual for manufacturing autologous fibrin tissue adhesive

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Abstract

The aim of this article is to provide a concise and simple technical manual for manufacturing autologous fibrin tissue adhesive derived from the precipitation of fibrinogen using a combination of ethanol and freezing for surgery.All materials and equipment needed to manufacture ethanol-based autologous fibrin tissue adhesive are listed. In addition, step-by-step instructions are provided to allow for easy and rapid fibrin adhesive production.Ethanol-based autologous fibrin tissue adhesive can be manufactured in under 60 minutes. Furthermore, at our institution the startup cost for manufacturing ethanol-based autologous fibrin tissue adhesive was under $2,500.00.Ethanol-based autologous fibrin tissue adhesive is a safe, reliable, and easily manufactured autologous fibrin tissue adhesive that can be made by a trained technician in any blood bank, pharmacy, or surgical laboratory.

Related Organizations

University of Illinois System
United States
University of Illinois at Urbana–Champaign
United States

Keywords

Ethanol, Freezing, Fibrinogen, Humans, Tissue Adhesives, Fibrin Tissue Adhesive

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