Increased soluble IL-2 receptor in serum of patients with systemic lupus erythematosus

descriptionPublicationkeyboard_double_arrow_right Article 01 Jun 1993 English Publisher:Springer Science and Business Media LLCJournal:Clinical Rheumatology, volume 12, pages 204-209 (issn: 0770-3198, eissn: 1434-9949,

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Authors: S. Sawada; H. Hashimoto; S. Iijma; Y. Tokano; Y. Matsukawa; M. Takei; H. Ishikawa; +5 Authors

doi: 10.1007/bf02231527

pmid: 8358979

Increased soluble IL-2 receptor in serum of patients with systemic lupus erythematosus

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Abstract

We estimated the concentration of soluble IL-2R (sIL-2R) in the serum of patients with systemic lupus erythematosus (SLE) and examined the relationship between the serum levels of sIL-2R and clinical features or laboratory data. We found that elevated levels of sIL-2R were present in the serum of SLE patients with discoid rash, and sIL-2R concentrations were correlated with the soluble CD4 and soluble CD8 concentrations but not with classical serological marker, anti-DNA antibody or complement titer.

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Keywords

Adult, Adolescent, CD8 Antigens, Osmolar Concentration, Receptors, Interleukin-2, DNA, Middle Aged, Complement Hemolytic Activity Assay, Solubility, Antibodies, Antinuclear, CD4 Antigens, Humans, Lupus Erythematosus, Systemic, Female, Longitudinal Studies

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