Pancreatic scans of 200 patients have been analyzed and presented. The pancreatic scan must be rigidly controlled technically if its maximum clinical value is to be achieved. An unequivocally normal pancreatic scan is strong evidence that the acinar portion of the gland is normal. In our experience, 89.5% of the patients who had normal pancreatic scans were judged to be clinically normal after 2 years of followup. A technically satisfactory abnormal scan correlated 94.1% with proven carcinoma of the pancreas. Based on the result of this study, it is our feeling that pancreatic photoscanning with75SE-methionine is a useful procedure in the diagnosis of pancreatic disease.