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A computer-assisted image-processing system for the analysis of autoradiographs of cerebral metabolic activity

descriptionPublicationkeyboard_double_arrow_right Article 01 Jun 1980Publisher:Springer Science and Business Media LLCJournal:Journal of Medical Systems, volume 4, pages 121-135 (issn: 0148-5598, eissn: 1573-689X,

Authors: Louis Sokoloff; Charles Goochee; Wayne S. Rasband;

doi: 10.1007/bf02222459

pmid: 7217804

A computer-assisted image-processing system for the analysis of autoradiographs of cerebral metabolic activity

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Abstract

A computerized image-processing system has been developed for quantitative analyses of the autoradiographs obtained with the [14C]deoxyglucose method. By means of this system, these cerebral metabolic images can be digitized and the resultant data can be manipulated for image construction, enhancement, enlargement, and microdensitometric analysis. It is also possible to generate quantitative color-coded metabolic maps that display the distribution of the actual rates of local glucose utilization throughout the entire central nervous system with a resolution conservatively estimated to be equivalent to that of a full-width-half-maximum of approximately 100 micron.

Related Organizations

National Institutes of Health
United States
National Institute of Mental Health
United States
United States Public Health Service
United States

Keywords

Computers, Brain, Deoxyglucose, Rats, Animals, Autoradiography, Carbon Radioisotopes, Energy Metabolism, Densitometry

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