A new inhibitor of decarboxylase of aromatic amino acids
Copyright policy ) W P, BURKARD; K F, GEY; A, PLETSCHER;
A new inhibitor of decarboxylase of aromatic amino acids
N-(DL-Seryl)-N′-(2,3,4-trihydroxybenzyl)hydrazin (Ro 4-4602) bewriktin vitro starke Hemmung der Decarboxylase, die durch Pyridoxal-5′-phosphat nicht und durch Dialyse nur wenig vermindert werden kann. Nach i.p. Applikation der Substanz kommt es zu starker Verminderung der Decarboxylase-Aktivitat und zu massiger Herabsetzung von 5-Hydroxytryptamin und Noradrenalin in verschiedenen Organen. Monoaminoxydase des Gehirns wirdin vivo durch Ro 4-4602 nicht beeinflusst.
- Roche (Switzerland) Switzerland
Amino Acids, Aromatic, Hydrazines, Carboxy-Lyases, Amino Acids
Amino Acids, Aromatic, Hydrazines, Carboxy-Lyases, Amino Acids
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This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
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