Prospective study of antigenemia, plasma viremia and lymphocytic viremia in HIV-infected hemophiliacs

descriptionPublicationkeyboard_double_arrow_right Article 01 May 1995 English Publisher:Springer Science and Business Media LLCJournal:European Journal of Clinical Microbiology & Infectious Diseases, volume 14, pages 400-405 (issn: 0934-9723, eissn: 1435-4373,

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Authors: S, Melón Garcia; M, de Oña Navarro; C, Rodriguez Pinto; M, Fernández Urgellés; A, Martinez Gutierrez; P, de la Iglesia; F J, Mendez García;

doi: 10.1007/bf02114895

pmid: 7556228

Prospective study of antigenemia, plasma viremia and lymphocytic viremia in HIV-infected hemophiliacs

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Abstract

A total of 186 blood samples from 24 HIV-1 seropositive hemophiliac patients, monitored every four months for 29 months, were investigated for the presence of viral antigen in plasma. In addition, peripheral blood mononuclear cells (PBMC) were cultured for HIV-1, using normal PBMC as a target for replication. Antigenemia was detected in 51% of the patients and from PBMC in 87.5% of the patients. The incidence of HIV isolation in asymptomatic patients (42.8%) was similar to that found in symptomatic patients (51.4%). Patients with opportunistic infections had a higher incidence of lymphocytic viremia (p 500 mg/day significantly lowered the appearance of antigenemia and lymphocytic viremia (p < 0.05).

Keywords

Adult, Adolescent, HIV Antigens, HIV Infections, Hemophilia A, Prognosis, HIV-1, Leukocytes, Mononuclear, Humans, Lymphocytes, Prospective Studies, Viremia, Zidovudine, Biomarkers

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