Preparation and androgenic activity of novel heterocyclic steroids
Copyright policy )Preparation and androgenic activity of novel heterocyclic steroids
Die Darstellung verschiedener A-Nor-5α-androstan-Verbindungen, die im A-Ring ein Schwefel-, Selen- oder Tellur-Atom haben, wird beschrieben. Sie besitzen, im Gegensatz zu den entsprechenden Oxa-Verbindungen, anabol-androgene Aktivitat. 2, 3-Dithia-5α-androstan-17β-ol-Acetat hatte ebenfalls hohe anabol-androgene Wirksamkeit. Daraus wird geschlossen, dass fUr die anabol-androgene Aktivitat, nicht die elektronischen, sondern die sterischen Eigenschaften der C-2 und C-3 Atome, beziehungsweise ihre Substituenten, von Bedeutung sind.
- University of California, San Francisco United States
Male, Muscles, Prostate, Seminal Vesicles, Organ Size, Heterocyclic Compounds, Sulfoxides, Androgens, Animals, Biological Assay, Sulfones, Norsteroids
Male, Muscles, Prostate, Seminal Vesicles, Organ Size, Heterocyclic Compounds, Sulfoxides, Androgens, Animals, Biological Assay, Sulfones, Norsteroids
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