Eflornithine

descriptionPublicationkeyboard_double_arrow_right Article 01 Oct 1989 English Publisher:Springer Science and Business Media LLCJournal:Pharmaceutisch Weekblad, volume 11, pages 69-75 (issn: 0031-6911, eissn: 1573-739X,

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Authors: I, Van Bogaert; A, Haemers;

doi: 10.1007/bf02110252

pmid: 2505225

Eflornithine

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Abstract

Eflornithine (alpha-difluoromethylornithine; DFMO) is a recently developed drug against African trypanosomiasis (sleeping sickness). After a short description of trypanosomiasis and the current treatment, the mechanism of action of eflornithine is discussed, some clinical data is given and attention is paid to recently discovered analogues of eflornithine. Some examples of combination therapy with eflornithine and possible applications are mentioned.

Related Organizations

University of Antwerp
Belgium

Keywords

Eflornithine, Trypanosomiasis, African, Trypanosoma brucei gambiense, Animals, Humans, Chagas Disease, Trypanocidal Agents

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