Oligomerization of cytosine-containing nucleotide analogs in aqueous solution

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1990 English Publisher:Springer Science and Business Media LLCJournal:Journal of Molecular Evolution, volume 30, pages 3-6 (issn: 0022-2844, eissn: 1432-1432,

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Authors: J, Visscher; A W, Schwartz;

doi: 10.1007/bf02102447

pmid: 2107322

Oligomerization of cytosine-containing nucleotide analogs in aqueous solution

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Abstract

Bisphosphoimidazolides of 2'-deoxycytidine and of its acyclic analog C can be oligomerized in aqueous solution in the presence of Mn(II). Under certain conditions, a range of products extending to at least the 20mer can be obtained. These products are of interest as possible templates for oligomerization of the complementary monomers.

Related Organizations

Radboud University Nijmegen
Netherlands

Keywords

Oligonucleotides, Magnesium, Biological Evolution, Deoxycytidine, Catalysis

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