
doi: 10.1007/bf02099923
pmid: 1901369
This paper is concerned with the divergence of synonymous codon usage and its bias in three homologous genes within vertebrate species. Genetic distances among species are described in terms of synonymous codon usage divergence and the correlation is found between the genetic distances and taxonomic distances among species under study. A codon usage clock is reported in alpha-globin and beta-globin. A method is developed to define the synonymous codon preference bias and it is observed that the bias changes considerably among species.
Base Composition, Gene Frequency, Sequence Homology, Nucleic Acid, Vertebrates, Animals, Humans, Codon, Biological Evolution
Base Composition, Gene Frequency, Sequence Homology, Nucleic Acid, Vertebrates, Animals, Humans, Codon, Biological Evolution
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