Utilization of pyrimidine precursors in tumors and liver of mice with ehrlich's ascites carcinoma

descriptionPublicationkeyboard_double_arrow_right Article 01 Dec 1970 English Publisher:Springer Science and Business Media LLCJournal:Bulletin of Experimental Biology and Medicine, volume 70, pages 1,414-1,417 (issn: 0007-4888, eissn: 1573-8221,

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Authors: N. A. Fedorov; V. N. Matveenko; E. F. Tikhonova;

doi: 10.1007/bf02066792

Utilization of pyrimidine precursors in tumors and liver of mice with ehrlich's ascites carcinoma

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Abstract

Investigation of the incorporation of labeled pyrimidine precursors into free pyrimidine nucleotides, RNA, and DNA of the liver and tumor cells from mice with Ehrlich's ascites carcinoma showed that the incorporation of C14-uridine and C14-orotic acid into the liver of tumor-carrying animals is reduced compared with that into the liver of healthy animals.

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