Toxicity of intravitreal oxiconazole
Copyright policy )Toxicity of intravitreal oxiconazole
Oxiconazole, a new imidazole derivative, has a broad antifungal spectrum in vitro and in vivo. Adult New Zealand white rabbits were injected intravitreally with doses ranging from 10 to 100 micrograms of this drug. Eyes were evaluated with preoperative and postoperative biomicroscopy and indirect ophthalmoscopy, electroretinography, and light microscopy. From these data, it was determined that an intravitreal injection containing a concentration of up to 100 micrograms per 0.1 milliliter of oxiconazole was nontoxic to the rabbit eye.
- University Medical Center New Orleans United States
- University of Illinois at Chicago United States
- Louisiana State University United States
- University Medical Center United States
- University of Illinois System United States
Vitreous Body, Fixatives, Time Factors, Electroretinography, Imidazoles, Animals, Rabbits, Eye, Injections
Vitreous Body, Fixatives, Time Factors, Electroretinography, Imidazoles, Animals, Rabbits, Eye, Injections
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