The evaluation of cotton twine as a new anti-inflammatory assay

descriptionPublicationkeyboard_double_arrow_right Article 01 May 1975 English Publisher:Springer Science and Business Media LLCJournal:Agents and Actions, volume 5, pages 128-132 (issn: 0065-4299, eissn: 1420-908X,

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Authors: C L, Rassaert; G, Dipasquale; S, O'Donoghue;

doi: 10.1007/bf02027353

pmid: 1155301

The evaluation of cotton twine as a new anti-inflammatory assay

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Abstract

A new anti-inflammatory assay is described, utilizing a subcutaneously implanted elongated section of cotton twine to induce granuloma in rats. The cotton twine irritant is easily introduced under the abdominal skin and after seven days a well formed granuloma is established. The procedure works effectively for both steroidal and non-steroidal anti-inflammatory drug evaluation. Consistency of the cotton twine eliminates individual weighing of each section and uniformity in compactness affords reproducible results.

Keywords

Drug Implants, Inflammation, Male, Gossypium, Granuloma, Anti-Inflammatory Agents, Methods, Animals, Rats

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