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image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Inflammation Researc...arrow_drop_down
image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
Inflammation Research
Article . 1994 . Peer-reviewed
License: Springer TDM
Data sources: Crossref
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Histamine and pacemaker shift in the sinoatrial node

Authors: E. Kevelaitis; R. Lazhauskas; R. Abraitis;

Histamine and pacemaker shift in the sinoatrial node

Abstract

We used the isolated superfused preparations of right atrium with the zone of the sinoatrial node of rabbits to study the effects of histamine on the location of the dominant pacemaker. The preparations were cut into four pieces and electrical activity was recorded in each fragment by means of a surface suction electrode with internal KCl perfusion. Under control conditions, the maximum frequency of monophasic potentials was found in the fragment with the central part of the sinoatrial node. Histamine (10(-5)M) increased spontaneous activity of all fragments. However, the maximum frequency of potentials was recorded in the fragment with the inferior part of the sinoatrial node. This effect of histamine was reversible upon washout. We conclude that histamine activates the latent pacemakers and induces a pacemaker shift towards the inferior part of the sinoatrial node.

Keywords

Electrophysiology, Biological Clocks, Animals, Heart Atria, Rabbits, In Vitro Techniques, Histamine, Potassium Chloride, Sinoatrial Node

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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
4
Average
Average
Average
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