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Effect of phosphonic analogues of glutamic acid on glutamate decarboxylase

descriptionPublicationkeyboard_double_arrow_right Article 01 May 1985 English Publisher:Springer Science and Business Media LLCJournal:Experientia, volume 41, pages 643-644 (issn: 0014-4754, eissn: 1420-9071,

Authors: Eugène Neuzil; A. Cassaigne; Anne-Marie Lacoste; S. Mansour;

doi: 10.1007/bf02007699

pmid: 3888659

Effect of phosphonic analogues of glutamic acid on glutamate decarboxylase

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Abstract

Among the phosphonic analogues of glutamic acid, only 4-amino-4-phosphono butyric acid, the compound which shows the highest affinity for pyridoxal phosphate, inhibits competitively both Escherichia coli and rat brain glutamate decarboxylases. Phosphinothricin, 2-amino-4-(methylphosphino)butyric acid, is a strong inhibitor of the mammalian enzyme.

Related Organizations

University of Bordeaux
France
University of Bordeaux
France

Keywords

Glutamate Decarboxylase, Organophosphonates, Brain, Rats, Kinetics, Structure-Activity Relationship, Glutamates, Pyridoxal Phosphate, Escherichia coli, Animals

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